GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs17401966 | 1 | rs12130220 | chr1:10359944 | PGD | chr1:10459085-10480200:+ | 0.2 | 5.72 | 1.39E-8 | Hepatocellular carcinoma |
| BRCA | cis | rs17030613 | 1 | rs12130243 | chr1:113169667 | ST7L | chr1:113066142-113162405:- | 0.55 | 11.63 | 1.57E-29 | Diastolic blood pressure;Blood pressure |
| BRCA | cis | rs6684514 | 1 | rs12130361 | chr1:156260301 | BGLAP | chr1:156182784-156213112:+ | 0.2 | 5.36 | 1.02E-7 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6688613 | 1 | rs12130629 | chr1:166953284 | TADA1 | chr1:166825751-166845654:- | -0.1 | -3.4 | 0.000688 | Refractive astigmatism |
| BRCA | cis | rs11799420 | 1 | rs12132221 | chr1:171685694 | VAMP4 | chr1:171669298-171711214:- | 0.19 | 5.4 | 8.35E-8 | Hippocampal atrophy |
| BRCA | cis | rs17401966 | 1 | rs12132635 | chr1:10430479 | PGD | chr1:10459085-10480200:+ | 0.23 | 6.31 | 4.09E-10 | Hepatocellular carcinoma |
| BRCA | cis | rs6684514 | 1 | rs12132794 | chr1:156281020 | BGLAP | chr1:156182784-156213112:+ | -0.2 | -5.33 | 1.17E-7 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs17030613 | 1 | rs12133583 | chr1:113240790 | ST7L | chr1:113066142-113162405:- | 0.58 | 12.99 | 6.34E-36 | Diastolic blood pressure;Blood pressure |
| BRCA | cis | rs4654899 | 1 | rs12133780 | chr1:21270808 | SH2D5 | chr1:21046225-21059330:- | 0.13 | 3.51 | 0.000468 | Superior frontal gyrus grey matter volume |
| BRCA | cis | rs9253 | 1 | rs12133933 | chr1:37958389 | SNIP1 | chr1:38002145-38019903:- | -0.19 | -3.81 | 0.000148 | Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs12143789 | 1 | rs12133982 | chr1:119464002 | WARS2 | chr1:119573841-119683295:- | 0.25 | 4.78 | 2.04E-6 | Waist-to-hip ratio adjusted for body mass index |
| BRCA | cis | rs6686842 | 1 | rs12134073 | chr1:41689283 | SCMH1 | chr1:41492875-41707788:- | -0.12 | -3.4 | 0.00069 | Height |
| BRCA | cis | rs12143789 | 1 | rs12134163 | chr1:119466993 | WARS2 | chr1:119573841-119683295:- | 0.25 | 4.82 | 1.66E-6 | Waist-to-hip ratio adjusted for body mass index |
| BRCA | cis | rs6684514 | 1 | rs12134983 | chr1:156290409 | BGLAP | chr1:156182784-156213112:+ | 0.19 | 5.12 | 3.57E-7 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs12143789 | 1 | rs12135657 | chr1:119470813 | WARS2 | chr1:119573841-119683295:- | 0.26 | 4.89 | 1.15E-6 | Waist-to-hip ratio adjusted for body mass index |